The aim of medicine is to apply the best available treatment for a particular disorder. To achieve this goal, standards have become established for the selection of the most effective therapy as the basis for best clinical practice. Technology has not been shown to be superior to intensively matched existing therapies. Research has been undertaken into the development and preliminary clinical testing of novel technologies including robotics, electrical stimulation, constraint-induced movement therapy, assistive orthoses, noninvasive brain stimulation, virtual reality and gaming devices. Translation of the research into clinical practice has been impeded by a lack of robust evidence of clinical effectiveness and usability. Technological advances continue to infuse the field of neurorehabilitation with both excitement and apprehension. A challenge for clinicians is to determine which of the growing number of devices or interventions available should be incorporated into their clinical practice, and when and with whom they should be offered, in order to best assist their patients in attaining the highest level of function and quality of life. Clinical applications of Brain-computer interface in Neurorehabilitation is Performed on patients who suffered neurological disabilities that include stroke, spinal cord injury, traumatic brain injury, neuromuscular disease, and other neurological disorders. Among these neurological disabilities, stroke is the leading cause of severe disabilities in the developed world.